Neno Kezić graduated in Architecture from the University of Zagreb in 1988 and began his professional career at Michel Hopkins & Partners in London. In 1990, he founded his own practice, Arhipolis, where he continues to work as principal architect.

His work spans a wide range of built and ongoing projects, alongside active participation in architectural competitions, juries, and exhibitions. Since 2004, he has been teaching at the University of Split, where he has served as Full Professor since 2011. He was a Visiting Professor at Keio University in Tokyo (2020/21).

Kezić is the recipient of several major awards, including the Vladimir Nazor Award (2013), Zagreb Salon (2012), Bernardo Bernardi (1991 and 1998), Drago Galic (2001), and was nominated for the EU Mies van der Rohe Award.